Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, due to the fact that vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids, and polycystic ovary syndrome.
Vitamin D and benign gynaecological diseases : a critical analysis of the current evidence / L. Buggio, E. Roncella, E. Somigliana, P. Vercellini. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 32:4(2016 Apr), pp. 259-263.
Titolo: | Vitamin D and benign gynaecological diseases : a critical analysis of the current evidence |
Autori: | RONCELLA, ELENA (Secondo) VERCELLINI, PAOLO PIETRO (Ultimo) |
Parole Chiave: | endometriosis; overdiagnosis.; polycystic ovary syndrome; uterine fibroids; vitamin D |
Settore Scientifico Disciplinare: | Settore MED/40 - Ginecologia e Ostetricia |
Data di pubblicazione: | apr-2016 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 16-nov-2015 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3109/09513590.2015.1111329 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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