Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, due to the fact that vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids, and polycystic ovary syndrome.

Vitamin D and benign gynaecological diseases : a critical analysis of the current evidence / L. Buggio, E. Roncella, E. Somigliana, P. Vercellini. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 32:4(2016 Apr), pp. 259-263. [10.3109/09513590.2015.1111329]

Vitamin D and benign gynaecological diseases : a critical analysis of the current evidence

L. Buggio
;
E. Roncella
Secondo
;
E. Somigliana;P. Vercellini
Ultimo
2016-04

Abstract

Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, due to the fact that vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids, and polycystic ovary syndrome.
endometriosis; overdiagnosis.; polycystic ovary syndrome; uterine fibroids; vitamin D
Settore MED/40 - Ginecologia e Ostetricia
16-nov-2015
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/329747
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