The kinetics of naproxen (NSAIDs), orally (OS) administered at the daily dose of 10 mg.kg-1 repeated for 5 consecutive days, was investigated in 5 healthy race-horses. The kinetics was described by a monocompartimental model. The drug showed an elimination half-life of 6.48 hours (T1/2el); the peak concentration (mean Cmax = 38.62 mcg.ml-1) was attained in about 3.25 hours (mean Tmax); the clearance (mean value) was 0.020 L.h-1.kg-1. The bioavailability (F = 89.31%) was calculated by comparing the oral AUC values and the intravenous AUC values (data reported in a previous paper).
Cinetica e biodisponibilita' del naproxene nel cavallo sportivo / A. Zonca, R. Villa, P.P. Cagnardi, P. Barili, S. Carli. - In: ATTI DELLA SOCIETÀ ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1825-4454. - 59:(2005), pp. 239-240. (Intervento presentato al 59.. convegno Convegno nazionale tenutosi a Viareggio nel 2005).
Cinetica e biodisponibilita' del naproxene nel cavallo sportivo
A. ZoncaPrimo
;R. VillaSecondo
;P.P. Cagnardi;P. BariliPenultimo
;S. CarliUltimo
2005
Abstract
The kinetics of naproxen (NSAIDs), orally (OS) administered at the daily dose of 10 mg.kg-1 repeated for 5 consecutive days, was investigated in 5 healthy race-horses. The kinetics was described by a monocompartimental model. The drug showed an elimination half-life of 6.48 hours (T1/2el); the peak concentration (mean Cmax = 38.62 mcg.ml-1) was attained in about 3.25 hours (mean Tmax); the clearance (mean value) was 0.020 L.h-1.kg-1. The bioavailability (F = 89.31%) was calculated by comparing the oral AUC values and the intravenous AUC values (data reported in a previous paper).
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