Flumequine kinetics, administered intravenously (i.v.) and intramuscularly (i.m.) at 20 mg.kg-1, was investigated in 6 healthy goats, and the kinetic parameters obtained related to minimal inhibitory concentrations (MIC90) reported in literature. After i.v. injection, flumequine distributed rapidly (t1/2α = 0.87 ± 0.15 h) but was eliminated slowly (t1/2β = 7.12 ± 1.27 h). After i.m. administration, peak serum level (Cmax= 7.40±0.5 μg.mL-1) and bioavailability (>90%) of the drug indicate that flumequine could have a good efficacy against systemic infections sustained by susceptible microorganisms.

Farmacocinetica della flumequina nella capra. Dati preliminari / R. Villa, A. Zonca, P. Cagnardi, P. Barili, S. Carli. - In: ATTI DELLA SOCIETÀ ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1825-4454. - 58:(2004), pp. 138-138. ((Intervento presentato al 58.. convegno Convegno nazionale tenutosi a Grado nel 2004.

Farmacocinetica della flumequina nella capra. Dati preliminari

R. Villa
Primo
;
A. Zonca
Secondo
;
P. Cagnardi;P. Barili
Penultimo
;
S. Carli
Ultimo
2004

Abstract

Flumequine kinetics, administered intravenously (i.v.) and intramuscularly (i.m.) at 20 mg.kg-1, was investigated in 6 healthy goats, and the kinetic parameters obtained related to minimal inhibitory concentrations (MIC90) reported in literature. After i.v. injection, flumequine distributed rapidly (t1/2α = 0.87 ± 0.15 h) but was eliminated slowly (t1/2β = 7.12 ± 1.27 h). After i.m. administration, peak serum level (Cmax= 7.40±0.5 μg.mL-1) and bioavailability (>90%) of the drug indicate that flumequine could have a good efficacy against systemic infections sustained by susceptible microorganisms.
Flumequina, capra, cinetica, biodisponibilità flumequine, goat, kinetics, bioavailability
Settore VET/07 - Farmacologia e Tossicologia Veterinaria
Società Italiana delle Scienze Veterinarie
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/32899
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