In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be used to define the failure of vitamin D treatment.
Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease : Predictive Factors / M. Cozzolino, A. Covic, B. Martinez-Placencia, K. Xynos. - In: AMERICAN JOURNAL OF NEPHROLOGY. - ISSN 0250-8095. - 42:3(2015 Nov), pp. 228-236.
|Titolo:||Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease : Predictive Factors|
COZZOLINO, MARIO GENNARO (Primo)
|Parole Chiave:||vitamin D failure; secondary hyperparathyroidism; chronic kidney disease|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||nov-2015|
|Data ahead of print / Data di stampa:||7-ott-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000441095|
|Appare nelle tipologie:||01 - Articolo su periodico|