We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.
Is it time to revise antiretrovirals dosing? : a pharmacokinetic viewpoint / D. Cattaneo, S. Baldelli, S. Castoldi, N. Charbe, V. Cozzi, S. Fucile, E. Clementi. - In: AIDS. - ISSN 1473-5571. - 28:16(2014 Oct 23), pp. 2477-2480.
Is it time to revise antiretrovirals dosing? : a pharmacokinetic viewpoint
D. CattaneoPrimo
;S. BaldelliSecondo
;N. Charbe;V. Cozzi;S. FucilePenultimo
;E. ClementiUltimo
2014
Abstract
We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
