What is known and objective: Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene. Case summary: A 12-year-old male received dantrolene 3 mg/kg/day in adjunct to baclofen 2 mg/kg/day, to improve spasticity. After 5 days of full-dose dantrolene, his dysphagia worsened and he developed pharyngeal spasm. Dantrolene was suspected for an adverse reaction and removed. The patient subsequently improved. What is new and conclusion: Causality analysis determined a probable relationship between dantrolene and pharyngeal spasm. This may be due to direct muscle contraction by dantrolene, an effect seen previously in vitro. Dantrolene can be combined to baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal and upper oesophageal sphincter spasm due to dantrolene. The possible mechanism involves a neglected activity of dantrolene, previously observed in vitro.
Pharyngeal spasticity due to dantrolene / F. Locatelli, M. Pozzi, P. Avantaggiato, M. Lanfranchi, L. Tufarulo, V. Amorelli, G. Rizzi, S. Radice, S. Galbiati, E. Clementi, S. Strazzer. - In: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. - ISSN 1365-2710. - 39:4(2014 Aug), pp. 449-451.
|Titolo:||Pharyngeal spasticity due to dantrolene|
CLEMENTI, EMILIO GIUSEPPE IGNAZIO (Penultimo)
|Parole Chiave:||adverse effect; paediatrics; traumatic brain injury; Baclofen; Child; Dantrolene; Deglutition Disorders; Drug Therapy, Combination; Humans; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle Spasticity; Pharyngeal Diseases|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||ago-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/jcpt.12161|
|Appare nelle tipologie:||01 - Articolo su periodico|
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