Uric acid to creatinine ratio (Ua/Cr) and lactate to creatinine ratio (L/ Cr) are diagnostic and prognostic biomarkers of perinatal asphyxia in neonatal human medicine. The aim of this work was to investigate urinary Ua/Cr and L/Cr in healthy and critically ill neonatal foals, and their possible diagnostic and prognostic role. Urines were collected by spontaneous micturition from 20 healthy foals within 24 h of age, and daily until day 7. Urines were also collected at admission and between 24 and 36 h after admission from 24 critically ill foals hospitalized within 3 days after birth. Ten foals were aﬀected by perinatal asphyxia and 14 by septicemia. Critically ill foals showed signiﬁcantly (p < 0.05) higher levels of Ua/Cr during the ﬁrst 2 days after birth; moreover non-surviving foals (n = 4 with septicemia) hospitalized within 24 h after birth showed signiﬁcantly (p < 0.05) higher levels compared to survivors (n = 20). Higher L/Cr levels were found in critically ill and non-surviving foals, but no signiﬁcant diﬀerences were found, probably due to the high individual variability. In conclusion, the Ua/Cr ratio could represent an early diagnostic and prognostic marker of disease in newborn foals.
Urinary uric acid to creatinine ratio and lactate to creatinine ratio in healthy and pathologic newborn foals / C. Castagnetti, S. Panzani, P. Scarpa, C. Pirrone, A. Zamboni, M.C. Veronesi. - In: REPRODUCTION IN DOMESTIC ANIMALS. - ISSN 0936-6768. - 48:suppl. 1(2013), pp. 115-115. ((Intervento presentato al 17. convegno Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) tenutosi a Bologna nel 2013.
|Titolo:||Urinary uric acid to creatinine ratio and lactate to creatinine ratio in healthy and pathologic newborn foals|
PANZANI, SARA (Secondo)
VERONESI, MARIA CRISTINA (Ultimo)
|Parole Chiave:||neonatal foals; urinary uric acid; creatinine; lactate|
|Settore Scientifico Disciplinare:||Settore VET/10 - Clinica Ostetrica e Ginecologia Veterinaria|
Settore VET/08 - Clinica Medica Veterinaria
|Data di pubblicazione:||2013|
|Data ahead of print / Data di stampa:||21-ago-2013|
|Appare nelle tipologie:||01 - Articolo su periodico|