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EnglishThe role of matricellular proteins in bacterial containment and in the induction of pathogen-specific adaptive immune responses is unknown. We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response. We show that SPARC was required for the development of organized acute inflammatory reactions with granuloma-like (GL) features and for the control of bacterial spreading to draining lymph nodes (DLNs). However, SPARC-related GL also inhibited dendritic cell (DC) migration to the DLNs and limited the development of adaptive immune response, thus conferring increased susceptibility to the pathogen. In SPARC-deficient mice, both DC migration and antigen-specific responses were restored against bacteria, leading to protective anti-S. typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks.
Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity / G. Rotta, G. Matteoli, E. Mazzini, P. Nuciforo, M.P. Colombo, M. Rescigno. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 205:3(2008), pp. 657-667.
| Titolo: | Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity |
| Autori: | RESCIGNO, MARIA (Corresponding) |
| Parole Chiave: | tumor-necrosis-factor; regulatory dendritic cells; mycobacterium-tuberculosis infection; extracellular-matrix; growth-factor; factor-alpha; endothelial-cells; tissue inhibitors; T-cells; in-vivo |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1084/jem.20071734 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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