The gut mucosa is exposed to a large community of commensal bacteria that are required for the processing of nutrients and the education of the local immune system. Conversely, the gut immune system generates innate and adaptive responses that shape the composition of the local microbiota. One striking feature of intestinal adaptive immunity is its ability to generate massive amounts of noninflammatory immunoglobulin A (IgA) antibodies through multiple follicular and extrafollicular pathways that operate in the presence or absence of cognate T-B cell interactions. Here we discuss the role of intestinal IgA in host-commensal mutualism, immune protection, and tolerance and summarize recent advances on the role of innate immune cells in intestinal IgA production.
The biology of intestinal immunoglobulin A responses / A. Cerutti, M. Rescigno. - In: IMMUNITY. - ISSN 1074-7613. - 28:6(2008), pp. 740-750.
Titolo: | The biology of intestinal immunoglobulin A responses |
Autori: | RESCIGNO, MARIA (Ultimo) |
Parole Chiave: | growth-factor-beta; FC-alpha-RI; common variable immunodeficiency; induced cytidine deaminase; class switch recombination; mucosal IgA responses; gut lamina propria; naive B-cells; dendritic cells; epithelial-cells |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2008 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.immuni.2008.05.001 |
Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
1-s2.0-S1074761308002367-main.pdf | Publisher's version/PDF | Administrator Richiedi una copia |