We studied the combined anti-human immunodeficiency virus type 1 (HIV-1) effects of a derivative of stroma-derived factor 1beta (SDF-1beta), Met-SDF-1beta, and a modified form of RANTES, aminooxypentane (AOP)-RANTES. The antiviral agents were tested singly or in combination at 95 and 99% virus inhibitory concentrations. Clinical R5 and X4 HIV-1 isolates were used. AOP-RANTES inhibited R5 but not X4 viruses, whereas Met-SDF-1beta had the opposite effect. Combinations of these compounds inhibited mixed infections with R5 and X4 viruses (95 to 99%), whereas single drugs were less inhibitory (32 to 61%). Combinations of R5 and X4 inhibitors are promising and deserve further evaluation
Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection : in vitro studies of mixed virus infections / S. Rusconi, S. La Seta Catamancio, P. Citterio, E. Bulgheroni, F. Croce, S.H. Herrmann, RE.O fford, M. Galli, M.S. Hirsch. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 74:19(2000 Oct), pp. 9328-9332.
Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection : in vitro studies of mixed virus infections
S. RusconiPrimo
;S. La Seta CatamancioSecondo
;P. Citterio;E. Bulgheroni;F. Croce;M. GalliPenultimo
;
2000
Abstract
We studied the combined anti-human immunodeficiency virus type 1 (HIV-1) effects of a derivative of stroma-derived factor 1beta (SDF-1beta), Met-SDF-1beta, and a modified form of RANTES, aminooxypentane (AOP)-RANTES. The antiviral agents were tested singly or in combination at 95 and 99% virus inhibitory concentrations. Clinical R5 and X4 HIV-1 isolates were used. AOP-RANTES inhibited R5 but not X4 viruses, whereas Met-SDF-1beta had the opposite effect. Combinations of these compounds inhibited mixed infections with R5 and X4 viruses (95 to 99%), whereas single drugs were less inhibitory (32 to 61%). Combinations of R5 and X4 inhibitors are promising and deserve further evaluationPubblicazioni consigliate
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