Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55–68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23–100.48). Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer / O. De Cobelli, C. Buonerba, D. Terracciano, B. Danilo, L. Giuseppe, P. Bove, V. Altieri, I. Coman, S. Perdonà, G. Facchini, M. Berretta, G.D. Lorenzo, P. Grieco, E. Novellino, R. Franco, M. Caraglia, C. Manini, V. Mirone, S.D. Placido, G. Sonpavde, M. Ferro. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 11:22(2015 Nov), pp. 3091-3098. [10.2217/fon.15.249]
Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer
O. De Cobelli;
2015
Abstract
Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55–68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23–100.48). Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
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