Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55–68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23–100.48). Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
|Titolo:||Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer|
|Parole Chiave:||Gleason score; prostate cancer; urotensin II receptor|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||nov-2015|
|Data ahead of print / Data di stampa:||18-set-2015|
|Digital Object Identifier (DOI):||10.2217/fon.15.249|
|Appare nelle tipologie:||01 - Articolo su periodico|