The frequency of normoblastemia in dogs receiving chemotherapy is unknown. To provide this information, we calculated the percentage and number of nucleated erythrocytes (nRBCs) in blood of dogs treated for lymphoma (n=284), mast cell tumour (n=40) or carcinoma (n=46). Relative normoblastemia (>1 or >5%) and absolute normoblastemia (>0.1 or >0.4×103μL-1) were found after administration of vincristine (49.3, 20.5, 42.5, 19.2%, respectively), carboplatin (37.0, 2.2, 34.8, 13.0%), cyclophosphamide (30.8, 7.7, 23.1, 7.7%), doxorubicin (25.0, 8.3, 21.7, 6.7%), vinblastine and prednisone (25.0; 5.0; 22.5; 7.5%). Absolute normoblastemia was very severe (>1.0×103 nRBCμL-1) after administration of vincristine (9.6%), doxorubicin (3.3%), vinblastine and prednisone (2.5%). Absolute normoblastemia negatively correlated with RBC counts (P<0.001) and positively (P<0.001) with reticulocyte and WBC counts, but correlation coefficients were low (-0.19, 0.37, 0.15). Vincristine, doxorubicin or vinblastine and prednisone may induce severe normoblastemia. This may increase WBC counts and mask neutropenia associated with chemotherapy.
Nucleated erythrocytes in blood smears of dogs undergoing chemotherapy / P. Moretti, A. Giordano, D. Stefanello, R. Ferrari, S. Castellano, S. Paltrinieri. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5810. - (2015 Jun 25). [Epub ahead of print]
Titolo: | Nucleated erythrocytes in blood smears of dogs undergoing chemotherapy |
Autori: | |
Parole Chiave: | Chemotherapy; Dog; Leukopenia; Normoblastemia; Veterinary (all) |
Settore Scientifico Disciplinare: | Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria Settore VET/09 - Clinica Chirurgica Veterinaria |
Data di pubblicazione: | 25-giu-2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/vco.12156 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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