BACKGROUND AND AIMS: The excessive and repeated use of antibiotics in medicine has led to the development of antibiotic-resistant microbial strains, including Staphylococcus aureus whose emergence of antibiotic-resistant strains has reduced the number of antibiotics available to treat clinical infections caused by this bacterium. In this study, antioxidant and antimicrobial activities of methanolic extract of Xanthium strumarium L. leaves were evaluated on methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MRSA) spp. MATERIALS AND METHODS: Antiradical and antioxidant activities X. strumarium L. leaf extract were evaluated based on its ability to scavenge the synthetic 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and by the paired diene method, respectively, whereas the antimicrobial activity was assayed by the disc diffusion method. STATISTICAL ANALYSIS: Data were subjected to analysis of variance following an entirely random design to determine the least significant difference at P < 0.05 using SPSS v. 11.5. RESULTS AND CONCLUSIONS: The IC50 values of the extract were 0.02 mg/mL and 0.09 mg/mL for the antioxidant and DPPH-scavenging capacity, respectively. X. strumarium extract affected both methicillin-sensitive Staphylococcus aureus and MRSA, though antibacterial activity was more effective on methicillin-susceptible S. aureus spp. The antibacterial and antioxidant activities exhibited by the methanol extract may justify the traditional use of this plant as a folk remedy worldwide.
In vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus auerus / J. Sharifi Rad , S.M. Hoseini Alfatemi , M. Sharifi Rad, M. Iriti. - In: ANCIENT SCIENCE OF LIFE. - ISSN 0257-7941. - 33:2(2013 Oct), pp. 109-113.
|Titolo:||In vitro antioxidant and antibacterial activities of Xanthium strumarium L. extracts on methicillin-susceptible and methicillin-resistant Staphylococcus auerus|
IRITI, MARCELLO (Ultimo)
|Parole Chiave:||1,1-diphenyl-2-picrylhydrazyl; Staphylococcus aureus; Xanthium strumarium L; antioxidant activity; methicillin-resistant Staphylococcus aureus; methicillin-sensitive Staphylococcus aureus|
|Settore Scientifico Disciplinare:||Settore AGR/12 - Patologia Vegetale|
|Data di pubblicazione:||ott-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.4103/0257-7941.139050|
|Appare nelle tipologie:||01 - Articolo su periodico|