Objective: Determination of the urinary levels of 2.5-hexanedione (2,5-HD) was performed in subjects belonging to the Italian general population to define the reference value for this metabolite. Materials and methods: Urine samples were collected from 123 healthy Italian subjects who had not been occupationally exposed to n-hexane or methyl-n-butyl ketone (60 men and 63 women; 53 living in urban areas and 70 living in rural areas; 36 smokers and 87 nonsmokers; 65 aged above 35 years and 58 aged below 35 years). The determinations were performed by a gas chromatography method using a flame ionization detector (FID). A quality-control step was realized by analysis of 78 of these samples by high-performance liquid chromatography (HPLC) with UV detection. Results and discussion: The distribution of 2,5-HD concentration was log-normal and the corresponding centiles at the 95% confidence interval were as follows: the 50th centile, 0.270 mg/l for men and 0.191 mg/l for women; the 75th centile, 0.352 and 0.330 mg/l, respectively, for men and women; and the 95th centile, 0.762 and 0.582 mg/l, respectively, for men and women. The reference value, calculated as the upper unilateral 95% tolerance interval at 95% of confidence, was 0.795 mg/l for men and 0.627 for women.
Determination of urinary 2,5-hexanedione in the general Italian population / P. Bavazzano, P. Apostoli, C. Balducci, G.B. Bartolucci, M. Buratti, P. Duca, G. Gori, V. Li Donni, L. Perbellini, A. Perico, C. Minoia. - In: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. - ISSN 0340-0131. - 71:4(1998 Jun), pp. 284-288.
|Titolo:||Determination of urinary 2,5-hexanedione in the general Italian population|
PERICO, LAURA (Penultimo)
MINOIA, FRANCESCA SERENA (Ultimo)
|Parole Chiave:||reference values; 2,5-hexanedione; urine|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||giu-1998|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s004200050282|
|Appare nelle tipologie:||01 - Articolo su periodico|