Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.
It's HIP to be a hub : new trends for old-fashioned proteins / M. Vecchi, P.P. Di Fiore. - In: THE JOURNAL OF CELL BIOLOGY. - ISSN 0021-9525. - 170:2(2005), pp. 169-171.
It's HIP to be a hub : new trends for old-fashioned proteins
P.P. Di FioreUltimo
2005
Abstract
Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.
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