Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.
Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit / A. Tozzi, A. de Iure, V. Bagetta, M. Tantucci, V. Durante, A. Quiroga Varela, C. Costa, M. Di Filippo, V. Ghiglieri, E.C. Latagliata, M. Wegrzynowicz, M. Decressac, C. Giampà, J.W. Dalley, J. Xia, F. Gardoni, M. Mellone, O.M. El Agnaf, M.T. Ardah, S. Puglisi Allegra, A. Björklund, M.G. Spillantini, B. Picconi, P. Calabresi. - In: BIOLOGICAL PSYCHIATRY. - ISSN 0006-3223. - 79:5(2016 Mar 01), pp. 402-414. [10.1016/j.biopsych.2015.08.013]
Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit
F. Gardoni;M. Mellone;
2016
Abstract
Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.
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