The aim of this study was to evaluate the safety of intra-articular (IA) lidocaine plus adrenaline for improving peri-operative analgesia in anaesthetised dogs undergoing arthroscopy of the elbow. A solution of lidocaine (L) 1.98% plus adrenaline 1:100.000 was administered via the IA route and its safety evaluated in terms of cardio- neuro- and chondro-toxicity. No bradycardia or hypotension was recorded from induction to the last observational time point. Signs of toxicity of the nervous system could have been masked by the general anaesthesia but lidocaine concentrations detected in the blood were lower than those thought to be capable of producing toxicity. The assessment of in vitro chondrotoxicity showed a dose- and time-dependent effect of lidocaine on the viability of articular cells. Adrenaline appeared to reduce the chondrotoxicity of 1% lidocaine, following an exposure of up to 30 min.

Intra-articular administration of lidocaine plus adrenaline in dogs : pharmacokinetic profile and evaluation of toxicity in vivo and in vitro / A. Di Salvo, E. Chiaradia, G. della Rocca, F. Mancini, R. Galarini, D. Giusepponi, V. De Monte, P. Cagnardi, M.L. Marenzoni, A. Bufalari. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 208:(2016 Feb), pp. 70-75. [10.1016/j.tvjl.2015.09.004]

Intra-articular administration of lidocaine plus adrenaline in dogs : pharmacokinetic profile and evaluation of toxicity in vivo and in vitro

P. Cagnardi;
2016

Abstract

The aim of this study was to evaluate the safety of intra-articular (IA) lidocaine plus adrenaline for improving peri-operative analgesia in anaesthetised dogs undergoing arthroscopy of the elbow. A solution of lidocaine (L) 1.98% plus adrenaline 1:100.000 was administered via the IA route and its safety evaluated in terms of cardio- neuro- and chondro-toxicity. No bradycardia or hypotension was recorded from induction to the last observational time point. Signs of toxicity of the nervous system could have been masked by the general anaesthesia but lidocaine concentrations detected in the blood were lower than those thought to be capable of producing toxicity. The assessment of in vitro chondrotoxicity showed a dose- and time-dependent effect of lidocaine on the viability of articular cells. Adrenaline appeared to reduce the chondrotoxicity of 1% lidocaine, following an exposure of up to 30 min.
Chondrotoxicity; Dog; Intra-articular administration; Lidocaine; Pharmacokinetics; Systemic toxicity
Settore VET/07 - Farmacologia e Tossicologia Veterinaria
Settore VET/09 - Clinica Chirurgica Veterinaria
feb-2016
9-set-2015
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/316477
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