Diabetic microangiopathy leads to lower limb ulcers that are very slow to heal. Pycnogenol was evaluated on diabetic ulcers in a controlled trial. Ulcer medications were used in 4 groups (30 patients): (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol; and (4) medications only (control group). Ulcerated areas and symptom scores were more reduced with the combined oral and local treatment (P < .05). Oral and local treatment were less effective, but still improved compared with the controls. Combined treatment produced 89% complete healing at 6 weeks versus 84% with local treatment and 85% with oral treatment; healing in controls was 61%. The combined treatment group and oral only group had better microcirculation after the combined treatment. Combined local and systemic application of Pycnogenol may offer a new treatment of diabetic ulcers. Local treatment also speeds ulcer healing.

Diabetic ulcers : microcirculatory improvement and faster healing with pycnogenol / G. Belcaro, M.R. Cesarone, B.M. Errichi, A. Ledda, A. Di Renzo, S. Stuard, M. Dugall, I. Pellegrini, G. Gizzi, P. Rohdewald, E. Ippolito, A. Ricci, M. Cacchio, G. Cipollone, I. Ruffini, F. Fano, M. Hosoi. - In: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. - ISSN 1076-0296. - 12:3(2006 Jul), pp. 318-323.

Diabetic ulcers : microcirculatory improvement and faster healing with pycnogenol

E. Ippolito;
2006

Abstract

Diabetic microangiopathy leads to lower limb ulcers that are very slow to heal. Pycnogenol was evaluated on diabetic ulcers in a controlled trial. Ulcer medications were used in 4 groups (30 patients): (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol; and (4) medications only (control group). Ulcerated areas and symptom scores were more reduced with the combined oral and local treatment (P < .05). Oral and local treatment were less effective, but still improved compared with the controls. Combined treatment produced 89% complete healing at 6 weeks versus 84% with local treatment and 85% with oral treatment; healing in controls was 61%. The combined treatment group and oral only group had better microcirculation after the combined treatment. Combined local and systemic application of Pycnogenol may offer a new treatment of diabetic ulcers. Local treatment also speeds ulcer healing.
Capillary filtration; Diabetic microangiopathy; Pycnogenol
Settore MED/22 - Chirurgia Vascolare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/31628
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