The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments. These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or auto-antibody-dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.
|Titolo:||Mechanisms of immune-mediated skin diseases : an overview|
|Parole Chiave:||Anti-endothelial cell antibodies; Anti-fibroblast antibodies; Anti-Ro/SSA antibodies; Atopic dermatitis; Keratinocytes; Skin; Systemic lupus erythematosus; Systemic sclerosis; T regulatory cells|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||01 - Articolo su periodico|