The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
Transgenic Mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on intracellular receptors, and method for the preparation thereof / A. Maggi, P. Ciana.
Transgenic Mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on intracellular receptors, and method for the preparation thereof
A. Maggi;P. Ciana
2014
Abstract
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
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