The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.
Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications / A. Bonetti, S. Pellegrino, P. Das, S. Yuran, R. Bucci, N. Ferri, F. Meneghetti, C. Castellano, M. Reches, M.L. Gelmi. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 17:18(2015 Sep 18), pp. 4468-4471.
Titolo: | Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications |
Autori: | BONETTI, ANDREA (Secondo) PELLEGRINO, SARA (Primo) GELMI, MARIA LUISA (Ultimo) |
Parole Chiave: | Drug-delivery system; peptide nanotubes; amino-acid; nanostructures; derivatives; helix; inducer; ph |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 18-set-2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/acs.orglett.5b02132 |
Appare nelle tipologie: | 01 - Articolo su periodico |