The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.
Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications / A. Bonetti, S. Pellegrino, P. Das, S. Yuran, R. Bucci, N. Ferri, F. Meneghetti, C. Castellano, M. Reches, M.L. Gelmi. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 17:18(2015 Sep 18), pp. 4468-4471. [10.1021/acs.orglett.5b02132]
Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted beta(2,3)-Diarylamino Acid and L-Alanine as Candidates for Biomedical Applications
A. BonettiSecondo
;S. PellegrinoPrimo
;R. Bucci;N. Ferri;F. Meneghetti;C. Castellano;M.L. GelmiUltimo
2015
Abstract
The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β(2,3)-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.File | Dimensione | Formato | |
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