In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours.
|Titolo:||Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen|
BIGANZOLI, ELIA (Secondo)
MARUBINI, ETTORE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||21-lug-2003|
|Digital Object Identifier (DOI):||10.1038/sj.bjc.6601060|
|Appare nelle tipologie:||01 - Articolo su periodico|