The present invention relates to tranylcypromine derivatives and to their use as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
Tranylcypromine Derivatives Useful as Inhibitors Demethylases LSD1 and LSD2 / S. Minucci, A. Mai, A. Mattevi.
Tranylcypromine Derivatives Useful as Inhibitors Demethylases LSD1 and LSD2
S. Minucci;
2011
Abstract
The present invention relates to tranylcypromine derivatives and to their use as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
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