Peripheral neuropathies are common neurologic disorders, but current treatments are limited. Among the different approaches to treat the acquired neuropathies due to traumatic injuries, the pharmacological interventions directed to Schwann cell may represent a useful and challenging opportunity. Following nerve damage the distal axon and the ensheathing Schwann cells degenerate, ensuing a process known as "Wallerian degeneration". Schwann cells then dedifferentiate and proliferate to support neurite outgrowth. In the recent years, several pharmacological agents that may promote the Schwann cell in its role of supporting nerve regeneration have been proposed. However, in view of increased understanding of the cellular mechanisms controlling neuron-glial interactions, a great attention has focused on neurotransmitters, neuroactive steroids, and neurohormones. In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury.
|Titolo:||Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration|
|Parole Chiave:||dorsal-root ganglia; rat sciatic-nerve; increases intracellular calcium; muscarinic receptor subtypes; gamma-aminobutyric-acid; axonal gaba-receptors; sensory neurons; spinal-cord; neuroactive steroids; protein-kinase|
|Settore Scientifico Disciplinare:||Settore BIO/17 - Istologia|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||10.1016/S0074-7742(09)87015-3|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|