Tissue microarrays in diffuse large B-cell lymphomas: are they really able to identify distinct prognostic groups in lymphomas of both nodal and extranodal origin?

Laszlo, D.; Pruneri, G.; Andreola, G.; Radice, D.; Calabrese, L.; Rafaniello, P.; Nassi, L.; Sammassimo, S.; Alietti, A.; Agazzi, A.; Vanazzi, A.; Martinelli, G.

doi:10.1177/1066896909345596

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Aims. Diffuse large B-cell lymphomas (DLBCL) can be divided into different subgroups (germinal center B-cell-like [GCB] and non-GCB) according to their gene expression profiles. Immunohistochemistry has been proposed as a surrogate for identifying these subgroups, but data about its efficacy in providing prognostic information are conflicting. Methods and results. This study retrospectively analyzed a series of 105 DLBCL, defined as GCB and non-GCB according to CD10, bcl-6, and MUM1 expression. All patients received a first-line anthracycline-based (CHOP-like) chemotherapy. A total of 50 patients (48%) were identified as GCB and 55 (52%) as non-GCB. The overall response rate was 89% (94/105), with 62 (59%) complete response. Disease progressions were equally distributed between the 2 subgroups and were not significantly different (P = .756) considering the primary site of involvement (nodal or extranodal). The median follow-up was 62 months (range 5-126 months). Overall survival at 5 years was not significantly different between the groups (P = .3468) and was 72.3% and 66.6% for GCB and non-GCB, respectively. Conclusion. The results do not support the prognostic value of GCB and non-GCB immunohistochemical categories in DLBCL of both nodal and extranodal origin. Furthermore, a limited number of antigens may be not sufficient to identify the same patterns defined by cDNA microarray.

Tissue microarrays in diffuse large B-cell lymphomas: are they really able to identify distinct prognostic groups in lymphomas of both nodal and extranodal origin? / D. Laszlo, G. Pruneri, G. Andreola, D. Radice, L. Calabrese, P. Rafaniello, L. Nassi, S. Sammassimo, A. Alietti, A. Agazzi, A. Vanazzi, G. Martinelli. - In: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. - ISSN 1066-8969. - 19:4(2011 Aug), pp. 417-424.

Titolo:	Tissue microarrays in diffuse large B-cell lymphomas: are they really able to identify distinct prognostic groups in lymphomas of both nodal and extranodal origin?
Autori:	D. Laszlo PRUNERI, GIANCARLO G. Andreola D. Radice L. Calabrese P. Rafaniello L. Nassi S. Sammassimo A. Alietti A. Agazzi A. Vanazzi G. Martinelli mostra contributor esterni nascondi contributor esterni
Parole Chiave:	non-Hodgkin's lymphomas; prognostic factors; tissue microarray; immunohistochemistry
Settore Scientifico Disciplinare:	Settore MED/08 - Anatomia Patologica
Data di pubblicazione:	ago-2011
Rivista:	INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1177/1066896909345596
Appare nelle tipologie:	01 - Articolo su periodico

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2434/297290

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