The aims of this study were to evaluate the impact of hepatitis B vaccination on the changing pattern of HBV infection in a former hyperendemic area (Afragola, South Italy), and to assess the long-term persistence of anti-HBs in two cohorts of individuals vaccinated as infants 18 and 23 years ago. Our data shows a significant decline in the prevalence of hepatitis B virus (HBV) markers in the general population from 1978 to 2006 (HBsAg: 13.4% versus 0.91%; anti-HBc: 66.9% versus 7.6%; p<0.001). Data from two cohorts of vaccinees provides further evidence regarding the long-term persistence of vaccine-induced anti-HBs. Data here reported indicates that the implementation of vaccination had a great impact in the control and prevention of hepatitis B in Italy.
Impact of hepatitis B vaccination in a highly endemic area of south Italy and long-term duration of anti-HBs antibody in two cohorts of vaccinated individuals / G. Da Villa, L. Romanò, A. Sepe, R. Iorio, N. Paribello, A. Zappa, A.R. Zanetti. - In: VACCINE. - ISSN 0264-410X. - 25:16(2007 Apr 20), pp. 3133-3136.
|Titolo:||Impact of hepatitis B vaccination in a highly endemic area of south Italy and long-term duration of anti-HBs antibody in two cohorts of vaccinated individuals|
ROMANO', LUISA (Secondo)
ZAPPA, ALESSANDRA (Penultimo)
ZANETTI, ALESSANDRO REMO (Ultimo)
|Parole Chiave:||HBV prevalence; Hepatitis B vaccination; Long-term protection|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||20-apr-2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.vaccine.2007.01.044|
|Appare nelle tipologie:||01 - Articolo su periodico|