Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography.
|Titolo:||Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues|
|Parole Chiave:||Micropatterning; Nanotopography; Cell culture; Neural network; Titanium oxide|
|Settore Scientifico Disciplinare:||Settore FIS/01 - Fisica Sperimentale|
|Data di pubblicazione:||lug-2011|
|Digital Object Identifier (DOI):||10.1016/j.msec.2011.02.006|
|Appare nelle tipologie:||01 - Articolo su periodico|