The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.
Carbohydrates: a phenol sandwich fights diabetes / A. Bernardi, S. Sattin. - In: NATURE CHEMICAL BIOLOGY. - ISSN 1552-4450. - 11:9(2015 Aug 18), pp. 635-636.
Carbohydrates: a phenol sandwich fights diabetes
A. BernardiPrimo
;S. SattinUltimo
2015
Abstract
The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.
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