Sudden Infant Death Syndrome (SIDS), despite the success of campaigns to reduce its risks, is the leading cause of infant death in the Western world. Even though the pathogenesis remains unexplained, brainstem abnormalities of the neuronal network that mediates breathing and protective responses to asphyxia, particularly in the arousal phase from sleep, are believed to play a fundamental role. This is the first study to identify, in SIDS, developmental defects of specific brainstem centers involved in hearing pathways, particularly in the cochlear and vestibular nuclei, in the superior olivary complex and in the inferior colliculus, suggesting a possible influence of the acoustic system on respiratory activity. In 49 SIDS cases and 20 controls an in-depth anatomopathological examination of the autonomic nervous system was performed, with the main aim of detecting developmental alterations of brainstem structures controlling both the respiratory and auditory activities. Overall, a significantly higher incidence of cytoarchitectural alterations of both the auditory and respiratory network components were observed in SIDS victims compared with matched controls. Even if there is not sufficient evidence to presume that developmental defects of brainstem auditory structures can affect breathing, our findings, showing that developmental deficit in the control respiratory areas are frequently accompanied by alterations of auditory structures, highlight an additional important element for the understanding the pathogenetic mechanism of SIDS.
Developmental alterations of the auditory brainstem centers : pathogenetic implications in sudden infant death syndrome / A.M. Lavezzi, G. Ottaviani, L. Matturri. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 357:1-2(2015), pp. 257-263.
|Titolo:||Developmental alterations of the auditory brainstem centers : pathogenetic implications in sudden infant death syndrome|
LAVEZZI, ANNA MARIA (Corresponding)
OTTAVIANI, GIULIA MARIA ELISA (Secondo)
MATTURRI, LUIGI (Ultimo)
|Parole Chiave:||SIDS; Auditory brainstem system; Respiratory brainstem system; Cochlear nuclei; Vestibular nuclei; Superior olivary complex; Inferior colliculus|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||2015|
|Centro di ricerca:||Centro di Ricerca "Lino Rossi" per lo studio e la prevenzione della morte perinatale del feto a termine e neonatale e della sindrome della morte improvvisa del lattante SIDS|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jns.2015.07.050|
|Appare nelle tipologie:||01 - Articolo su periodico|