The new chiral auxiliary (R)-2-ethylthio-1-(phenylethyl)-(R)-binaphthyl phosphite, 1, and three stable Pd(0) olefin complexes containing this chelate, 2-4, have been synthesized. The structure of the maleic anhydride complex 3 has been determined by X-ray diffraction methods. Solution details for 2-4 and aspects of their dynamics have been elucidated via 2-D NMR spectroscopy. The fumaronitrile complex 2 exchanges intramolecularly, whereas the maleic anhydride and pentenedione derivatives, 3 and 4, respectively, exchange intermolecularly. Ligand 1 has been used as auxiliary in the Pd, Rh, and Ir regio- and enantioselective allylic alkylation reactions of PhCH=CHCH(OAc)R, R = H, Me, Et, with the anion of dimethyl malonate. Modest to good selectivities are reported.
|Titolo:||Chiral phosphito-thioether complexes of palladium(0) : comments on the Pd, Rh, and Ir regio-and-enantioselective allylic alkylations of PhCH=CHCH(OAc)R, R = H, Me, Et|
ALBINATI, ALBERTO (Ultimo)
|Parole Chiave:||homogeneous catalysis; substitution-reaction; crystal-structure; NMR-spectroscopy; ligands; configuration; thioglucose; amination|
|Settore Scientifico Disciplinare:||Settore CHIM/03 - Chimica Generale e Inorganica|
|Data di pubblicazione:||25-ott-1999|
|Digital Object Identifier (DOI):||10.1021/om990452o|
|Appare nelle tipologie:||01 - Articolo su periodico|