To investigate the role of oral contraceptives and their interaction with thrombophilia in ischemic stroke, a case-control study on women with a first ischemic stroke when younger than 45 years was carried out. Oral contraceptives doubled the risk of ischemic stroke in the first 6-18 months of use and hyperhomocysteinemia increased the risk by 3.5-fold. Carriers of factor V Leiden or prothrombin G20210A were not found to have a statistically significant increased risk. The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia. (copyright)2006 Ferrata Storti Foundation.
|Titolo:||Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke|
MANNUCCI, PIER MANNUCCIO (Ultimo)
|Parole Chiave:||Genetics; Homocysteinemia; Risk factors; Thrombophilia|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||01 - Articolo su periodico|