The cellular composition of the islet of Langerhans is essential to ensure its physiological function. Morphophysiological islet abnormalities are present in type 2 diabetes but the relationship between fasting plasma glucose (FPG) and islet cell composition, particularly the role of delta cells, is unknown. We explored these questions in pancreases from baboons (Papio hamadryas) with FPG ranging from normal to type 2 diabetic values.

Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas) / R. Guardado Mendoza, C. Perego, G. Finzi, S. La Rosa, C. Capella, L.M. Jimenez-Ceja, L.A. Velloso, M.J.A. Saad, F. Sessa, F. Bertuzzi, S. Moretti, E.J. Dick, A.M. Davalli, F. Folli. - In: DIABETOLOGIA. - ISSN 1432-0428. - 58:8(2015 Aug), pp. 1814-1826. [10.1007/s00125-015-3625-5]

Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas)

C. Perego
Secondo
;
S. Moretti;A.M. Davalli
Penultimo
;
F. Folli
Ultimo
2015-08

Abstract

The cellular composition of the islet of Langerhans is essential to ensure its physiological function. Morphophysiological islet abnormalities are present in type 2 diabetes but the relationship between fasting plasma glucose (FPG) and islet cell composition, particularly the role of delta cells, is unknown. We explored these questions in pancreases from baboons (Papio hamadryas) with FPG ranging from normal to type 2 diabetic values.
Islet of Langerhans; diabetes; somatostatin; apoptosis; pancreas; insulin
Settore BIO/09 - Fisiologia
Settore MED/13 - Endocrinologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/294111
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