The progress in assay methodology, from the use of radioactive tracers to chemiluminescent signals, from competitive to chromatographic techniques and from serum or urine to saliva has considerably impacted on hormonal measurements. The clinician now may choose among multiple tests but the inherent variability in cortisol and ACTH secretion, coupled to lack of harmonization among assay procedures and normal ranges mandates careful interpretation of any result. The present review will examine factors which affect interpretation of cortisol and ACTH measurements and their impact on tests used for management of Cushing's syndrome.
Variability in laboratory parameters used for management of Cushing's syndrome / F. Pecori Giraldi, A.G. Ambrogio. - In: ENDOCRINE. - ISSN 1355-008X. - 50:3(2015 Dec), pp. 580-589. [10.1007/s12020-015-0676-9]
Variability in laboratory parameters used for management of Cushing's syndrome
F. Pecori Giraldi
Primo
;A.G. AmbrogioUltimo
2015
Abstract
The progress in assay methodology, from the use of radioactive tracers to chemiluminescent signals, from competitive to chromatographic techniques and from serum or urine to saliva has considerably impacted on hormonal measurements. The clinician now may choose among multiple tests but the inherent variability in cortisol and ACTH secretion, coupled to lack of harmonization among assay procedures and normal ranges mandates careful interpretation of any result. The present review will examine factors which affect interpretation of cortisol and ACTH measurements and their impact on tests used for management of Cushing's syndrome.File | Dimensione | Formato | |
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