Hashimoto's encephalopathy (HE) is a rare neurological disorder with a heterogeneous group of neurological symptoms associated with high titres of anti-thyroid antibodies. Clinical manifestations may include encephalopathic features such as seizures, behavioural and psychiatric manifestations, movement disorders and coma. The objective of this presentation is to describe a patient with this rare and controversial clinical syndrome mimicking Creutzfeldt-Jakob disease, associated with a Hashimoto euthyroid thyroiditis and with a significant response to high dose intravenous prednisone. The responsiveness of this syndrome to steroids suggests that this disorder involves immune pathogenic mechanisms, as previous reviews reported.

Steroid-responsive Hashimoto encephalopathy mimicking Creutzfeldt-Jakob disease / D. Santoro, I. Colombo, I. Ghione, L. Peverelli, N. Bresolin, M. Sciacco, A. Prelle. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 32:4(2011 Aug 11), pp. 719-722.

Steroid-responsive Hashimoto encephalopathy mimicking Creutzfeldt-Jakob disease

D. Santoro;I. Colombo;I. Ghione;L. Peverelli;N. Bresolin;
2011-08-11

Abstract

Hashimoto's encephalopathy (HE) is a rare neurological disorder with a heterogeneous group of neurological symptoms associated with high titres of anti-thyroid antibodies. Clinical manifestations may include encephalopathic features such as seizures, behavioural and psychiatric manifestations, movement disorders and coma. The objective of this presentation is to describe a patient with this rare and controversial clinical syndrome mimicking Creutzfeldt-Jakob disease, associated with a Hashimoto euthyroid thyroiditis and with a significant response to high dose intravenous prednisone. The responsiveness of this syndrome to steroids suggests that this disorder involves immune pathogenic mechanisms, as previous reviews reported.
encephalopathy; Hashimoto; anti-thyroid antibodies; steroids
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/290938
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