HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD(n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
Titers of herpes simplex virus Type 1 antibodies positively correlate with Grey Matter volumes in Alzheimer's disease / R. Mancuso, F. Baglio, M. Cabinio, E. Calabrese, A. Hernis, R. Nemni, M. Clerici. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 38:4(2014), pp. 741-745. [10.3233/JAD-130977]
Titers of herpes simplex virus Type 1 antibodies positively correlate with Grey Matter volumes in Alzheimer's disease
M. Cabinio;R. NemniPenultimo
;M. ClericiUltimo
2014
Abstract
HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD(n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.File | Dimensione | Formato | |
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