HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD(n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
Titers of herpes simplex virus Type 1 antibodies positively correlate with Grey Matter volumes in Alzheimer's disease / R. Mancuso, F. Baglio, M. Cabinio, E. Calabrese, A. Hernis, R. Nemni, M. Clerici. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 38:4(2014), pp. 741-745.
|Titolo:||Titers of herpes simplex virus Type 1 antibodies positively correlate with Grey Matter volumes in Alzheimer's disease|
NEMNI, RAFFAELLO (Penultimo)
CLERICI, MARIO SALVATORE (Ultimo)
|Parole Chiave:||Alzheimer's disease; HSV-1; humoral immunity; magnetic resonance imaging|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/26 - Neurologia
Settore MED/37 - Neuroradiologia
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3233/JAD-130977|
|Appare nelle tipologie:||01 - Articolo su periodico|