The subependymal layer (SEL) of the adult mammalian brain provides a continuous supply of newborn cells that migrate to the olfactory bulb (OB) where they differentiate into interneurons. These newly generated cells migrate tangentially to the OB within a dense meshwork of astrocytic cells, organized to form tangentially oriented channels (glial tubes). The central nervous system is able to synthesize a variety of steroids. Among these, we analyzed the effects of progesterone (P) and its neuroactive metabolites dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), administered by intraventricular injection, on the SEL of the adult rat. We found that THP and DHP, but not their precursor P, modify glial tubes organization and decrease immunoreactivity for glial associated proteins in SEL astrocytes. Moreover P metabolites reduce the proliferative activity within the SEL.
|Titolo:||Neurogenesis in the subependymal layer of the adult rat: a role for neuroactive derivatives of progesterone|
|Parole Chiave:||Adult neurogenesis; Glial tubes; Neuroactive steroids; Neurogenetic niche; Progesterone metabolites; Subependymal layer|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||10.1196/annals.1286.032|
|Appare nelle tipologie:||01 - Articolo su periodico|