Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.
The transcellular railway: insights into leukocyte diapedesis / E. Dejana. - In: NATURE CELL BIOLOGY. - ISSN 1465-7392. - 8:2(2006), pp. 105-107.
The transcellular railway: insights into leukocyte diapedesis
E. DejanaPrimo
2006
Abstract
Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.
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