IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

Introduction: Mechanical ventilation delivers energy (mechanical work) to the respiratory system at each breath. We used an animal model of high pressure-volume ventilation to determine if a relationship exists between energy delivered to the respiratory system and development of ventilator-induced lung injury. Methods: Fifteen piglets were ventilated with different energy loads, obtained with constant tidal volume (38±3 ml/kg, strain >2.5) and different respiratory rates (3-6-9-12-15 breaths/min). The study protocol lasted 54 hours or less if massive lung edema developed. At the beginning of the study, a dynamic pressure-volume curve of the respiratory system was obtained to determine the energy delivered per minute (energy delivered per breath times respiratory rate). Endexpiratory CT-scans were performed at baseline and at the end of the study to measure the increase in lung weight during mechanical ventilation. Results: Energy delivered per minute to the respiratory system ranged from 3.0 J/min to 28.5 J/min (median 15.5 J/min). A ROC curve analysis showed that an energy delivered of 16.7 J/min had 100% sensitivity and 100% specificity in predicting an increase in lung weight greater than 10% at the end of the study. Figure 1 shows the relationship between the energy delivered per minute and the percentage increase in lung weight. Conclusions: In our model of high pressure-volume ventilation it was possible to identify an energy threshold above which mechanical ventilation caused ventilator-induced lung injury.

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