The concept of convergent synthesis can be extended to combinatorial chemistry in order to obtain collections of products characterized by considerable chemical diversity and a certain molecular complexity. In this work, a library consisting of three carboxylic acids containing a benzimidazolonic functionality with variations at two positions was synthesized on solid phase. After cleavage, this library was combined with a second library consisting of 16 solid-supported amines containing two points of variation. IRORI technology was used for the split-and-mix synthesis of the final 48 members library.
|Titolo:||Solid-phase convergent synthesis of a benzoimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines|
|Autori interni:||BARLOCCO, DANIELA (Penultimo)|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1021/cc049901k|
|Appare nelle tipologie:||01 - Articolo su periodico|