Activation of the pacemaker ("funny," I-f) current during diastole is the main process underlying generation of the diastolic depolarization and spontaneous activity of cardiac pacemaker cells. I-f modulation by autonomic transmitters is responsible for the chronotropic regulation of heart rate. Given its role in pacemaking, I-f has been a major target of investigation aimed to exploit its rate-controlling function in a clinical perspective. In this short review, we describe some of the most recent clinically relevant applications of the concept of I-f-based pacemaking.
Titolo: | The pacemaker current : from basics to the clinics |
Autori: | BARBUTI, ANDREA FRANCESCO (Primo) BARUSCOTTI, MIRKO (Secondo) DI FRANCESCO, DARIO (Ultimo) |
Parole Chiave: | Biological pacemaker; Bradycardia; Heart-rate lowering agents; Pacemaker current |
Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia |
Data di pubblicazione: | 2007 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | 10.1111/j.1540-8167.2006.00736.x |
Appare nelle tipologie: | 01 - Articolo su periodico |
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