Activation of the pacemaker ("funny," I-f) current during diastole is the main process underlying generation of the diastolic depolarization and spontaneous activity of cardiac pacemaker cells. I-f modulation by autonomic transmitters is responsible for the chronotropic regulation of heart rate. Given its role in pacemaking, I-f has been a major target of investigation aimed to exploit its rate-controlling function in a clinical perspective. In this short review, we describe some of the most recent clinically relevant applications of the concept of I-f-based pacemaking.
The pacemaker current : from basics to the clinics / A. Barbuti, M. Baruscotti, D. DiFrancesco. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1045-3873. - 18:3(2007), pp. 342-347. [10.1111/j.1540-8167.2006.00736.x]
The pacemaker current : from basics to the clinics
A. BarbutiPrimo
;M. BaruscottiSecondo
;D. DifrancescoUltimo
2007
Abstract
Activation of the pacemaker ("funny," I-f) current during diastole is the main process underlying generation of the diastolic depolarization and spontaneous activity of cardiac pacemaker cells. I-f modulation by autonomic transmitters is responsible for the chronotropic regulation of heart rate. Given its role in pacemaking, I-f has been a major target of investigation aimed to exploit its rate-controlling function in a clinical perspective. In this short review, we describe some of the most recent clinically relevant applications of the concept of I-f-based pacemaking.
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