The “funny” (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
From funny current to HCN channels: 20 years of excitation / E.A. Accili, C. Proenza, M. Baruscotti, D. DiFrancesco. - In: NEWS IN PHYSIOLOGICAL SCIENCES. - ISSN 0886-1714. - 17:1(2002), pp. 32-37.
From funny current to HCN channels: 20 years of excitation
M. BaruscottiPenultimo
;D. DifrancescoUltimo
2002
Abstract
The “funny” (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
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