Background: Current multicomponent scores that predict mortality in COPD patients mightunderestimate the systemic component of COPD. Therefore, we evaluated the accuracy ofcirculating levels of proadrenomedullin (MR-proADM) alone or combined withthe ADO(Age, Dyspnoea, airflow Obstruction), updated ADO or BOD (Body mass index,airflow Obstruction, Dyspnoea) index to predict all-cause mortality in stable COPD patients. Methods: This study pooled data of 1285 patients from the COMIC and PROMISE-COPD study. Results: Patients with high MR-proADM levels (≥0.87nmol/l) had a 2.1 fold higher risk of dying than those with lower levels (p<0.001). Based on the C-statistic, the ADOA index (ADO plus MR-proADM) (C=0.72) was the most accurate predictor followed by the BODA (BOD plus MR-proADM) (C=0.71) and the updated ADOA index (updated ADO plus MR-proADM) (C=0.70). Adding MR-proADM to ADO and BOD was superior in forecasting 1- and 2-year mortality. The net percentages of persons with events correctly reclassified (NRI+) within respectively 1-year and 2-year was 31% and 20% for ADO, 31% and 20% for updated ADO and 25% and 19% for BOD. The net percentages of persons without events correctly reclassified (NRI-) within respectively 1-year and 2-year was 26% and 27% for ADO, 27% and 28% for updated ADO and 34% and 34% for BOD. Conclusions: Adding MR-proADM increased the predictive power of BOD, ADO and updated ADO index.

Adrenomedullin optimises mortality prediction in COPD patients / M. Brusse-Keizer, M. Zuur-Telgen, J. van der Palen, P. VanderValk, H. Kerstjens, W. Boersma, F. Blasi, K. Kostikas, B. Milenkovic, M. Tamm, D. Stolz. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - 109:6(2015 Jun), pp. 734-742.

Adrenomedullin optimises mortality prediction in COPD patients

F. Blasi;
2015

Abstract

Background: Current multicomponent scores that predict mortality in COPD patients mightunderestimate the systemic component of COPD. Therefore, we evaluated the accuracy ofcirculating levels of proadrenomedullin (MR-proADM) alone or combined withthe ADO(Age, Dyspnoea, airflow Obstruction), updated ADO or BOD (Body mass index,airflow Obstruction, Dyspnoea) index to predict all-cause mortality in stable COPD patients. Methods: This study pooled data of 1285 patients from the COMIC and PROMISE-COPD study. Results: Patients with high MR-proADM levels (≥0.87nmol/l) had a 2.1 fold higher risk of dying than those with lower levels (p<0.001). Based on the C-statistic, the ADOA index (ADO plus MR-proADM) (C=0.72) was the most accurate predictor followed by the BODA (BOD plus MR-proADM) (C=0.71) and the updated ADOA index (updated ADO plus MR-proADM) (C=0.70). Adding MR-proADM to ADO and BOD was superior in forecasting 1- and 2-year mortality. The net percentages of persons with events correctly reclassified (NRI+) within respectively 1-year and 2-year was 31% and 20% for ADO, 31% and 20% for updated ADO and 25% and 19% for BOD. The net percentages of persons without events correctly reclassified (NRI-) within respectively 1-year and 2-year was 26% and 27% for ADO, 27% and 28% for updated ADO and 34% and 34% for BOD. Conclusions: Adding MR-proADM increased the predictive power of BOD, ADO and updated ADO index.
Biomarker; Chronic obstructive pulmonary disease; Mortality determinants
Settore MED/10 - Malattie dell'Apparato Respiratorio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/279956
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