Four new acyclic diterpene glycosides named capsianosides (1-4), together with 12 known compounds, were isolated from the fresh sweet pepper fruits of Capsicum annuum L., a plant used as a vegetable food, spice, and external medicine. The chemical structures of new natural compounds, as well as their absolute configurations, were established by means of spectroscopic data including infrared, high-resolution mass spectrometry, and one-and two-dimensional nuclear magnetic resonance and by chemical derivatization. The known capsidiol (11) showed bacteriostatic properties in vitro against Helicobacter pylori with a minimum inhibitory concentration (MIC) of 200 mu g/mL when compared with the commercial drug metronidazole (MIC, 250 mu g/mL). Some purified components were also tested for their antioxidant activities.
|Titolo:||New constituents of sweet Capsicum annuum L. fruits and evaluation of their biological activity|
|Autori interni:||FICO, GELSOMINA|
|Parole Chiave:||2D-NMR; Antioxidant activity; Capsianosides; Capsicum annuum L.; Helicobacter pylori; Liquid chromatography; Solanaceae|
|Settore Scientifico Disciplinare:||Settore BIO/15 - Biologia Farmaceutica|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||10.1021/jf061404z|
|Appare nelle tipologie:||01 - Articolo su periodico|