The neuroleptic butyrophenone drug spiroperidol (8-[4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro [4,5]decan-4-one) and related compounds are valuable tools for mapping the dopamine receptors in the brain. During the development of the radiochemical synthesis of these compounds with very short-lived isotopes suitable for positron emission tomography studies, positive electron impact mass spectrometric information was obtained. Ion series are present in the spectra of all 12 compounds studied, which unambiguously allow recognition of type and site of substitution on the spiro system.

Electron impact mass spectrometry of substituted 1,3,8-triazaspiro[4,5]decan-4-ones / B. Danieli, F.M. Rubino, L. Zecca. - In: BIOMEDICAL & ENVIRONMENTAL MASS SPECTROMETRY. - ISSN 0887-6134. - 18:11(1989 Nov), pp. 1000-1004.

Electron impact mass spectrometry of substituted 1,3,8-triazaspiro[4,5]decan-4-ones

B. Danieli
Primo
;
F.M. Rubino
Secondo
;
1989

Abstract

The neuroleptic butyrophenone drug spiroperidol (8-[4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro [4,5]decan-4-one) and related compounds are valuable tools for mapping the dopamine receptors in the brain. During the development of the radiochemical synthesis of these compounds with very short-lived isotopes suitable for positron emission tomography studies, positive electron impact mass spectrometric information was obtained. Ion series are present in the spectra of all 12 compounds studied, which unambiguously allow recognition of type and site of substitution on the spiro system.
Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Spiperone
Settore CHIM/01 - Chimica Analitica
nov-1989
Article (author)
File in questo prodotto:
File Dimensione Formato  
04_1989 BEMS spiperones EI.pdf

accesso riservato

Descrizione: fotocopia pdf del reprint
Tipologia: Publisher's version/PDF
Dimensione 300.21 kB
Formato Adobe PDF
300.21 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/278511
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 2
social impact