In newborn babies, endothelin-1 (ET-1), a potent vasoconstrictor, increases during septicaemia and severe respiratory syndromes. Since Equine Neonatal Sepsis (ENS) and Perinatal Asphyxia Syndrome (PAS) are major causes of morbidity and mortality in newborn foals and since no information on the concentration of ET-1 in healthy and sick foals has been reported yet, the aims of this study were: 1) to define the serum concentration of Big ET-1 in healthy neonatal foals during the first week of age; 2) to preliminarily explore the diagnostic and prognostic role of Big ET-1 during ENS and PAS. Six healthy and 23 sick foals affected by ENS and/or PAS were enrolled in the study. In healthy foals, Big ET-1 concentration increased in the first hours of life until 24 hours after birth, it remained constant during the first 3 days, then gradually decreased becoming significantly lower from day 4 onwards (P<0.05). In sick foals, only 26.1% of animals showed higher values of Big ET-1 than controls at admission and no difference between surviving and non-surviving foals was found. Since in non-surviving foals Big ET-1 remained over the maximum value recorded in clinically healthy horses or, when normal at admission, increased over time, this study suggested that repeated measurement of Big ET-1 during hospitalization may be helpful in monitoring the course of the disease. In conclusion, possible prognostic information may be obtained by repeated analysis of Big ET-1 during hospitalization, but further studies are needed. Six healthy and 23 sick foals affected by ENS and/or PAS were enrolled in the study. In healthy foals, Big ET-1 concentration increased in the first hours of life until 24 hours after birth, it remained constant during the first 3 days, then gradually decreased becoming significantly lower from day 4 onwards (P<0.05). In sick foals, only 26.1% of animals showed higher values of Big ET-1 than controls at admission and no difference between surviving and non-surviving foals was found. Since in non-surviving foals Big ET-1 remained over the maximum value recorded in clinically healthy horses or, when normal at admission, increased over time, this study suggested that repeated measurement of Big ET-1 during hospitalization may be helpful in monitoring the course of the disease. In conclusion, possible prognostic information may be obtained by repeated analysis of Big ET-1 during hospitalization, but further studies are needed.
Endothelin 1 in healthy foals and in foals affected by neonatal diseases / A. Giordano, C. Castagnetti, S. Panzani, S. Paltrinieri, F. Freccero, M.C. Veronesi. - In: THERIOGENOLOGY. - ISSN 1879-3231. - (2015). [10.1016/j.theriogenology.2015.04.026]
Endothelin 1 in healthy foals and in foals affected by neonatal diseases
A. GiordanoPrimo
;S. Panzani
;S. Paltrinieri;M.C. VeronesiUltimo
2015
Abstract
In newborn babies, endothelin-1 (ET-1), a potent vasoconstrictor, increases during septicaemia and severe respiratory syndromes. Since Equine Neonatal Sepsis (ENS) and Perinatal Asphyxia Syndrome (PAS) are major causes of morbidity and mortality in newborn foals and since no information on the concentration of ET-1 in healthy and sick foals has been reported yet, the aims of this study were: 1) to define the serum concentration of Big ET-1 in healthy neonatal foals during the first week of age; 2) to preliminarily explore the diagnostic and prognostic role of Big ET-1 during ENS and PAS. Six healthy and 23 sick foals affected by ENS and/or PAS were enrolled in the study. In healthy foals, Big ET-1 concentration increased in the first hours of life until 24 hours after birth, it remained constant during the first 3 days, then gradually decreased becoming significantly lower from day 4 onwards (P<0.05). In sick foals, only 26.1% of animals showed higher values of Big ET-1 than controls at admission and no difference between surviving and non-surviving foals was found. Since in non-surviving foals Big ET-1 remained over the maximum value recorded in clinically healthy horses or, when normal at admission, increased over time, this study suggested that repeated measurement of Big ET-1 during hospitalization may be helpful in monitoring the course of the disease. In conclusion, possible prognostic information may be obtained by repeated analysis of Big ET-1 during hospitalization, but further studies are needed. Six healthy and 23 sick foals affected by ENS and/or PAS were enrolled in the study. In healthy foals, Big ET-1 concentration increased in the first hours of life until 24 hours after birth, it remained constant during the first 3 days, then gradually decreased becoming significantly lower from day 4 onwards (P<0.05). In sick foals, only 26.1% of animals showed higher values of Big ET-1 than controls at admission and no difference between surviving and non-surviving foals was found. Since in non-surviving foals Big ET-1 remained over the maximum value recorded in clinically healthy horses or, when normal at admission, increased over time, this study suggested that repeated measurement of Big ET-1 during hospitalization may be helpful in monitoring the course of the disease. In conclusion, possible prognostic information may be obtained by repeated analysis of Big ET-1 during hospitalization, but further studies are needed.File | Dimensione | Formato | |
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