Diet has been suggested to have a role on endometrial cancer risk, but few data are available on the role of dietary patterns on this neoplasm. A case-control study was carried out in Italy, including 454 women with endometrial cancer and 908 hospital controls admitted to the same hospitals for acute, non-neoplastic diseases. Dietary information was based on a reproducible and valid food frequency questionnaire. A posteriori dietary patterns were obtained using principal component factor analysis on 28 nutrients. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from multiple logistic regression models conditioned on age and study center, and adjusted for major known confounding factors. Positive associations were found for the "Western-type diet" (OR. = 1.63, 95% CI: 1.12-2.38, for the highest versus the lowest quartile category) and the "Animal-derived nutrients and polyunsaturated fatty acids" patterns (OR. = 1.76, 95% CI: 1.23-2.52). The corresponding risk estimates among women with a body mass index ≥30 were 2.08 (95% CI: 0.92-4.69) and 2.30 (95% CI: 1.03-5.16) for the two patterns, respectively. No association was found for the other three patterns (i.e., "Vitamins and fiber", OR. = 0.96, 95% CI: 0.67-1.37, "Starch-rich", OR. = 0.99, 95% CI: 0.69-1.42, and "Other fats", OR. = 1.03, 95% CI: 0.70-1.52). This study indicates that dietary habits characterized by high intakes of animal products increase endometrial cancer risk, the association being appreciably stronger for obese women.
Nutrient-based dietary patterns and endometrial cancer risk: an Italian case-control study / F. Bravi, P. Bertuccio, F. Turati, D. Serraino, V. Edefonti, L. Dal Maso, A. Decarli, M. Montella, A. Zucchetto, C. La Vecchia, C. Bosetti, M. Ferraroni. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - 39:1(2015 Feb), pp. 66-72. [10.1016/j.canep.2014.12.003]
Nutrient-based dietary patterns and endometrial cancer risk: an Italian case-control study
F. Bravi
;P. BertuccioSecondo
;F. Turati;V. Edefonti;L. Dal Maso;A. Decarli;C. La Vecchia;M. FerraroniUltimo
2015
Abstract
Diet has been suggested to have a role on endometrial cancer risk, but few data are available on the role of dietary patterns on this neoplasm. A case-control study was carried out in Italy, including 454 women with endometrial cancer and 908 hospital controls admitted to the same hospitals for acute, non-neoplastic diseases. Dietary information was based on a reproducible and valid food frequency questionnaire. A posteriori dietary patterns were obtained using principal component factor analysis on 28 nutrients. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from multiple logistic regression models conditioned on age and study center, and adjusted for major known confounding factors. Positive associations were found for the "Western-type diet" (OR. = 1.63, 95% CI: 1.12-2.38, for the highest versus the lowest quartile category) and the "Animal-derived nutrients and polyunsaturated fatty acids" patterns (OR. = 1.76, 95% CI: 1.23-2.52). The corresponding risk estimates among women with a body mass index ≥30 were 2.08 (95% CI: 0.92-4.69) and 2.30 (95% CI: 1.03-5.16) for the two patterns, respectively. No association was found for the other three patterns (i.e., "Vitamins and fiber", OR. = 0.96, 95% CI: 0.67-1.37, "Starch-rich", OR. = 0.99, 95% CI: 0.69-1.42, and "Other fats", OR. = 1.03, 95% CI: 0.70-1.52). This study indicates that dietary habits characterized by high intakes of animal products increase endometrial cancer risk, the association being appreciably stronger for obese women.File | Dimensione | Formato | |
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