Background and aims: High glycemic load (GL) has been associated with increased coronary heart disease (CHD) risk. We evaluated whether preference of low-GL foods conveys incremental benefits with respect to CHD, especially to people adhering to the traditional Mediterranean diet (MD). Methods and results: We analyzed data from the Greek European Prospective Investigation into Cancer and Nutrition, including 20,275 participants free of cardiovascular diseases, cancer, or diabetes at baseline and without incident diabetes. Subjects completed a validated, semi-quantitative food frequency questionnaire at enrollment. We calculated a 10-point MD adherence score and the dietary GL, and estimated hazard ratios (HRs) for CHD incidence and mortality through Cox proportional hazard regression. After a median follow-up of 10.4 years, 417 participants developed CHD, and 162 died from the disease. A significant positive association of GL with CHD incidence emerged (HR for the highest versus the lowest tertile=1.41, 95% confidence interval, CI: 1.05-1.90). HRs for CHD mortality exceeded unity but were not statistically significant. The association with GL was stronger among subjects with higher body mass index. High adherence to MD with low/moderate GL was associated with lower risk of CHD incidence (HR=0.61, CI: 0.39-0.95) and mortality (HR=0.47, 95% CI: 0.23-96). Conclusion: High dietary GL increases the risk of CHD. Compared to a high GL diet with suboptimal adherence to the traditional Mediterranean pattern, a low/moderate GL diet that also conforms to the traditional MD principles could lead to a 40% reduced risk for CHD, and over 50% reduced risk for death from CHD.
Glycemic load and coronary heart disease in a Mediterranean population: the EPIC Greek cohort study / F. Turati, V. Dilis, M. Rossi, P. Lagiou, V. Benetou, M. Katsoulis, A. Naska, D. Trichopoulos, C. La Vecchia, A. Trichopoulou. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 25:3(2015 Mar), pp. 336-342.
|Titolo:||Glycemic load and coronary heart disease in a Mediterranean population: the EPIC Greek cohort study|
TURATI, FEDERICA (Corresponding)
LA VECCHIA, CARLO VITANTONIO BATTISTA (Penultimo)
|Parole Chiave:||Diet; Glycemic load; Coronary heart diseases; Cohort study; Mediterranean diet|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||mar-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.numecd.2014.12.002|
|Appare nelle tipologie:||01 - Articolo su periodico|