In the past few years, there have been advances in the treatment of neuroendocrine tumours (NETs) and improvements in our understanding of NET biology. However, the benefits to patients have been relatively modest and much remains yet to be done. The 'Hallmarks of Cancer', as defined by Hanahan and Weinberg, provide a conceptual framework for understanding the aberrations that underlie tumourigenesis and to help identify potential targets for therapy. In this study, our objective is to review the major molecular characteristics of NETs, based on the recently modified 'Hallmarks of Cancer', and highlight areas that require further research.
Hallmarks of gastrointestinal neuroendocrine tumours : implications for treatment / A. Walenkamp, G. Crespo, F.F. Maya, R. Fossmark, P. Igaz, A. Rinke, G. Tamagno, G. Vitale, K. Öberg, T. Meyer. - In: ENDOCRINE-RELATED CANCER. - ISSN 1351-0088. - 21:6(2014 Dec), pp. R445-R460.
|Titolo:||Hallmarks of gastrointestinal neuroendocrine tumours : implications for treatment|
|Parole Chiave:||cancer; neuroendocrine tumours; treatment; tumourigenesis|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||dic-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1530/ERC-14-0106|
|Appare nelle tipologie:||01 - Articolo su periodico|