Group A . Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the . emm gene encoding the M protein, but despite the high number of distinct . emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A . Streptococcus" and "acute rheumatic fever": the prevalence of peculiar . emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific . emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between . emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.
Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever / S. Esposito, S. Bianchini, M. Fastiggi, M. Fumagalli, L. Andreozzi, D. Rigante. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 14:7(2015), pp. 616-621. [10.1016/j.autrev.2015.03.001]
Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever
S. EspositoPrimo
;S. BianchiniSecondo
;M. Fumagalli;
2015
Abstract
Group A . Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the . emm gene encoding the M protein, but despite the high number of distinct . emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A . Streptococcus" and "acute rheumatic fever": the prevalence of peculiar . emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific . emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between . emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.File | Dimensione | Formato | |
---|---|---|---|
1-s2.0-S1568997215000634-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
310.29 kB
Formato
Adobe PDF
|
310.29 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.